February 28, 2018

A Degree For Life: The Job Market for PhDs Past and Present


Perspectives For PhD Graduates
The amount of PhD holders in Germany has greatly increased since the 1980s, producing many more graduates than available positions in academia [1]. Since then, the surplus of PhD degrees on the market has presumably been the cause of changed job perspectives for graduates. In the past, the traditional PhD-postdoc-professor career seemed more predefined for young scientists. Nowadays, the PhD bears importance as a title that represents more than just scientific expertise and the key to becoming a professor.
Outside of academia, a PhD title, regardless of the field it is in, is worshipped as a sign of highly valuable personal skills such as motivation, responsibility, perseverance and ambition. These traits are extremely important for leading positions in any profession [1]. Thus, scientists holding a PhD are appreciated in research and development in industry, in consulting, in patent law, scientific writing, sales and much more [2].

"The PhD Factory" by Pina Knauff


The Changing Face of Grad School
In the last few decades, the quality of PhD education has improved. Graduate schools were founded to turn the classical student-professor relationship to a more structured and interdisciplinary system. This helped shorten the graduation time and increase the quality of the degree [3]. Nonetheless, the prospects of long-term employment in academia remain poor in Germany [4].
One advance was the introduction of the junior professor position with tenure track option in 2002, representing an alternative to the classic Habilitation [5]. More recently, in 2015, a draft bill was passed to prevent short-term contracts in academia [6]. Despite these steps, Germany still lacks promising career prospects for PhD graduates in academia. There is clearly much room for improvement. 


Pina Knauff, PhD Student AG Wulczyn

February 26, 2018

BioBusiness Summer School

From June 26th to 30th 2017, I participated in the ninth edition of the BioBusiness Summer School in Amsterdam. Having always been interested in the combination of business with healthcare, I found the call for the course to be just what I had been looking for. I had high expectations – and they were fulfilled. In the short but very efficient five-day course, I learned an incredible amount. We had lectures with biotech entrepreneurs, big company CEOs, R&D scientists, venture capitalists, patent attorneys, CFOs (finance specialists), consultants, business developers... to name a few. On the final day, we headed to the Bio Science Park in Leiden (one of the top five life sciences clusters in Europe) and visited Janssen, a pharmaceutical company of Johnson & Johnson. There was also plenty of time for networking, interacting with the speakers and getting to know the other 80 young and enthusiastic participants.

Credit: BioBusiness Summer School / Hyphen Projects

Interested?
The BioBusiness Summer School is organized by Hyphen Projects and happens once a year. Although participation costs are not exactly cheap (€1,115 in 2017), they can be covered by conference and travel funds of a PhD scholarship. Registration deadline is March 1, 2018.



Mariana Cerdeira, PhD Student AG Harms

February 23, 2018

How Do Sports Affect Our Mind?

Sports are well-known to be good for our physical health. Many studies have confirmed the effectiveness of regular physical activity in the primary and secondary prevention of several diseases like cardiovascular disease, diabetes, cancer, hypertension, obesity, osteoporosis and premature death. Exercising appears to have a direct relationship with many aspects of our health status, i.e., exercising more leads to further improvement in physical well-being [1]. The next question is: what is the effect of sports on our mind?
 
Source: http://bit.ly/1U7mgoT
Physical activity helps our brain in many ways. It decreases anxiety and depression, protects from loss of cognitive function in people with a risk of Alzheimer's and conserves cognitive brain functions across one's lifespan. Likewise, it helps healthy people by improving sleep, reducing the risk of Alzheimer's and other neurodegenerative diseases [2,3,4,5].
Excercise Improves Mood Instantly
Our mood also benefits from physical activity. Regular exercise was verified to improve mental well-being in the general population. It increases our quality of life by enhancing self-esteem, improving mood and reducing stress [2]. Not only do sports help us in the long run, but they were shown to improve our mood almost instantaneously. Most likely, if you do 20 sit-ups right now, you will feel happier immediately (once you catch your breath) [6].
So the next time you go for a run, know that you are not only taking care of your body but also of your brain!

[1] Warburton et al., CMAJ, 2006
[2] Fox, Public Health Nutr, 1999
[3] Lautenschlager et al., JAMA, 2008
[4] Scarmeas et al., JAMA, 2009
[5] Kramer and Erickson, Trends Cogn Sci, 2007
[6] Yeung, J Psychosom Res, 1996

By Michelle Livne, PhD Student AG Sobesky

February 21, 2018

Korean Food: Revamped

The Olympics in South Korea are coming to an end on Sunday. If you got interested in the Korean culture and food, you definitely need to check out these restaurants in Berlin!

via Wikimedia Commons

Korean food has been taking Berlin by storm - it seems to be the trendy thing to enjoy nowadays - kimchi rolls, bulgogi (grilled meat) with a side order of mandu (dumplings), all washed down with some silky soju (rice liqour). If you do happen to be cool enough to be seen in these dining establishments, you are in "the know" of people who enjoy the gastronomic landscape of the city.
But it's not as if Korean restaurants are new to the scene: Gung Jeon for instance is a staple hang out amongst the Korean community, usually packed with expat or exchange students at lunch (with their secret lunch specials) with well beloved classic dishes which remind them of home - a warm bowl of seafood soup, a hearty plate of egg noodles with black bean sauce. Here, they serve the food straight up, with warm service and a homley atmosphere. It might be slightly intimidating for the non-Korean, as the clientele seems to already be in the know-how. German is hardly to be heard. Here, if you're a non-Korean, you must walk in with a poker face of confidence. "I know exactly what I am doing!"

Gung Jeon
Kurfürstendamm 134
10711 Berlin
+49 30 89541892
http://www.gungjeon.de/

Ixhthy's is the more grungy cousin of Gung Jeon - an Imbiss run by three Korean widows, blatantly pushing their Christian faith to every diner by wallpapering every possible inch with verses from the Bible. The Bibimbap - a popular dish amongst novices to Korean food - is exactly how it should be: sizzling hot, spicy to the point where your tongue hurts, and so delicious and satisfying from the generous serving of sesame oil and water spinach that you want to cuddle someone for an hour afterwards.
 Ixhthy
Pallasstrasse 21
10781 Berlin
+49 30 81474769
The new kids on the block take on a more sleek angle. Stylized décor, red lipsticked clientele with asymmetrical haircuts and an unseemly snooty gaze. This is the new Korean food scene in town. A well beloved establishment among this crowd of hipster joints is Kimchi Princess in Kreuzberg. Unmistakable Korean cookery is at work (I checked: the kitchen IS staffed with Korean cooks though I could have told you without having peeked), while the service staff is more international. The owner is half Korean himself, born in Germany. In a dimly lit high-ceilinged space with cool simple décor and red lighting, this is indeed the place to be nowadays. Just don't even think about walking in without having made a reservation first, and be aware that service on weekends can be slow from the many orders from packed tables. Kimchi Princess offers Korean food on steroids: delicious, sexy, young and hip. 
 Kimchi Princess
Skalitzer Str. 36
10999 Berlin, Germany
+49 163 4580203

By Gina Eom
This article originally appeared in Vol. 04 - Issue 3 - Brain Stimulation

February 19, 2018

CNS Newsletter Poll: Mate Selection in Neuroscientists


Who we choose to fall in love and start a family with has gathered considerable interest over the past few decades. The common perception is that men and women prefer different characteristics in their potential mates. The two principal theories contesting these different preferences are based on perspectives drawn from the study of evolution and social structure.

The evolutionary (Darwinistic) perspective assumes that successful mate choice behaviors continue to influence current mate selection because the behavior led to continued existence and prosperity of the human species [1]. Sex differences between men and women have evolved because they have historically faced different environmental and social pressures [2]. The parental investment model proposed by Trivers in 1972 further suggests that this is because men and women differ in the level of parental investment required to ensure the survival of the species. Thus, their mating behaviors evolved accordingly. While women invest extensive physiological resources in producing offspring, men invest more outside resources beyond the act of conception [3].
In contrast, the social structure perspective proposes that sexually differentiated mate selection results from contrasting social positions that men and women have historically occupied within society [2,4]. These types of societal constraints and gender expectations still persist. In an attempt to maximize resources, women who are delegated to roles of less power and resources seek out these characteristics in potential mates. They can offer commodities such as physical beauty, fertility, and sexual pleasure that are desired by men [2,4,5].
Both hypotheses are supported by ample evidence that can be reviewed in Shoemake 2007 [6].
Here, we used a short online poll to investigate possible sex differences and differences associated with career stage regarding mate selection of Berlin neuroscientists.
The survey comprised three questions: 1) ''What is your gender?'' 2) ''What is your position in neuroscience research?'' 3) ''What are the first four qualities you look for in a partner?” Categories were the following: age, cleanliness, ethnicity, financial security, intelligence, kindness, nerdiness, physical attraction, religion, sense of humor, social status, trustworthiness, and other. The survey was prepared on surveymonkey.com and sent to the Berlin Neuroscience community via mailing lists of Medical Neurosciences, Mind and Brain, Bernstein Center for Computational Neuroscience as well as the forum of the staff of the Department of Experimental Neurology. Answers were collected between April 28 and May 2, 2014.
126 responses were collected for the poll. One response had to be excluded since no answers were given to the questions. Out of the 125 answers, 62 participants were male, 61 female, one preferred not to answer and one chose “other”. Of the remaining 125 participants, 23 were students, 58 PhD students, 5 technicians, 20 postdocs, 4 group leaders, 10 professors, and 5 other (Fig. 1).

Fig. 1. Sociodemographic distribution of the participants

Neuroscientists Look for Intelligence, Physical Attraction Rates Only Third
Overall, intelligence (88.6%) was the most frequently reported quality that respondents looked for in their partners, followed by sense of humor (74.0%), physical attraction (68.3%), trustworthiness (60.2%), and kindness (58.5%) (Fig. 2). All other options had less than 10% votes, except for other (11.4%): age (8.1%), social status (7.3%), cleanliness (6.5%), nerdiness (5.7%), religion (3.3%), financial status (2.4%), and ethnicity (1.6%).


Fig. 2. Gender differences in mate selection


Male and Female Neuroscientists Desire Similar Qualities in their Partner
Both male and female participants rated the same top five qualities. The only differences across gender occurred with respect to physical attraction and sense of humor. For men, physical attraction was the second most frequent criterion, whereas only about half of the participating women reported it (80.6 vs. 55.7%, χ²(1, N=123)=8.81, p=0.003). Sense of humor was significantly more preferred by women compared to men (82.0 vs. 66.1%, χ²(1, N=123)=4.01, p=.045).


Neuroscientists Look for the Same Qualities Independent of Career Stage
Due to the low responses from technicians and 'other', we did not include these groups in the analysis. The responses from group leaders and professors were grouped for the same reason. All four groups – students, PhD students, postdocs, group leaders/professors – rated the top five qualities – intelligence, physical attraction, sense of humor, trustworthiness, and kindness – almost equally frequent. The more advanced in their career stage, the more important their partners' intelligence was rated by neuroscientists. Interestingly, postdocs rated physical attraction substantially lower than the other three groups, while they rated kindness substantially higher. Postdocs also had the highest score, even if not as pronounced, for trustworthiness and sense of humor. Only group leaders/professors rated social status as a quality of high importance. A Pearson's chi-squared test was performed and no relationship was found between career stage and any of the mate selection criteria investigated in this study.
Fig. 3. Career stage and mate selection

Discussion
We discovered that male and female neuroscientists have similar mate selection criteria which differ only when it comes to physical attraction. Intelligence was found to be the most frequently reported criterion. A relationship between career stage and mate selection criteria was not found.
In our study, we found intelligence, physical attraction, sense of humor, trustworthiness, and kindness to be the five key attributes both men and women look for in their mate. This goes in line with the immense amount of literature on mate preference that generally indicates a preference for intelligence, emotional stability, honesty and trustworthiness, an exciting overall personality, and – of course – a physically attractive appearance [7].



NEUROSCIENTISTS RATE INTELLIGENCE AS THE MOST IMPORTANT FACTOR IN THEIR PARTNER
 

Interestingly, our study suggests that neuroscientists rate intelligence as the most important factor in their partner – or at least, that is what we would like to believe. According to the matching hypothesis, people are more likely to form and succeed in a relationship with a partner who is equally socially desirable, which often refers to physical attractiveness [8]. On average, women tend to be attracted to men who are taller than they are and vice versa. While men want women with full breasts and lips, low waist-hip ratio, and a young appearance, women prefer men with broad shoulders, narrow waist, V-shaped torso, and masculine facial dimorphism. In addition, both seem to be attracted by a symmetrical face [9-11]. Even when on a purely platonic level, it was shown that people – especially men – tend to be drawn to others that they perceive as similarly attractive [12]. And sure, you probably know one or two successful couples where both partners are not necessarily attractive to the same degree. In this case, the less attractive partner possesses compensating qualities such as status and wealth [13]. Yet, it is not entirely surprising that intelligence is highly ranked. It was previously shown that people unconsciously attribute positive characteristics, e.g. intelligence, to physically attractive people [14]. This association was found to be stronger for men compared to women [15]. Prokosch and colleagues proposed a general fitness factor (f-factor) where intelligence and physical attractiveness are positively correlated because both reflect the quality of the genes and developmental stability [16]. 

NO RELATIONSHIP BETWEEN CAREER STAGE AND MATE SELECTION CRITERIA

Surprisingly, social status was ranked very low in this study, and only group leaders and professors seem to have a preference for it. According to the literature, women have a substantial preference for high social status and wealth [17,18]. In a large US study, men and women were asked how willing they would be to marry someone who possessed a variety of characteristics. While men were significantly less willing than women to marry someone who was “not good looking,” women were significantly less willing than men to marry a partner who was “not likely to hold a steady job” and who “would earn less than you.” However, they showed that both characteristics matter to men and women – just to a different degree [19]. 
We did not find a relationship between career stage and any of the mate selection criteria investigated here. Yet, group leaders and professors tend to pay more attention to social status. We can only speculate that being a neuroscientist or a researcher in academia favors a certain kind of person (which would also explain the lack of gender differences). Why postdocs, in particular, ranked physical attraction much lower than the other groups and tend to value sense of humor, kindness, and trustworthiness more, we'll leave up to your imagination.

What you think your partner should be like and how your beloved turns out to be might be completely different. That’s love! 

Limitations of this Study
This study is greatly limited by the short online poll and low number of respondents. A more detailed study on the mates and reproductive success of Berlin neuroscientists would provide a deeper insight on the actual selection criteria and evolutionary fitness of neuroscientists.

Acknowledgements
We would like to thank Anna Pajkert for helping with the statistical analysis of the data.

[1] Kenrick, Advan Exp Soc Psychol, 1994
[2] Eagly and Wood, Amer Psychol, 1999
[3] Trivers, “Parental investment and sexual selection”, in Campbell, B. (Ed.), Sexual Selection and the Descent of Man (pp. 136-179). Chicago: Aldine, 1972
[4] Howard et al, J Pers Soc Psychol, 1987
[5] Buss and Barnes, J Pers Soc Psychol, 1986
[6] Shoemake, J Scientific Psychol, 2007
[7] Regan, “The Mating Game. A Primer on Love, Sex, and Marriage”, Chapter 1: “Mate Preferences”, 2nd Edition, California State University, Los Angeles, 2008
[8] Feingold, Psychol Bull, 1988
[9] Perrett et al, Nature, 1998
[10] Nettle, Proc Biol Sci, 2002
[11] Glassenberg et al, Arch Sex Behav, 2010
[12] Feingold, J Pers Soc Psychol, 1990
[13] Myers, Social psychology, New York: McGraw-Hill Higher Education, 10th ed., 2009
[14] Dion et al, J Pers Soc Psychol, 1972
[15] Kanazawa, Intelligence, 2011
[16] Prokosch et al, Intelligence, 2005
[17] Buss and Schmitt, Psychol Rev, 1993
[18] Feingold, Psychol Bull, 1992
[19] Sprecher et al, J Pers Soc Psychol, 1994

by Marietta Zille
this article originally appeared 2014 in CNS Volume 7, Issue 2, Neuroscience of Love

February 16, 2018

The Course of True Love Never Did Run Smooth


The Nature of Relationships from a Scientific Perspective

If you peek into your own relationship(s) or those of friends, you might also recognize that there are some differences in behavior depending on the duration of the relationship. And that many of them, unfortunately, do not have a happy ending, as reflected in a divorce rate > 50% of marriages in Western societies [1]. Within this article, we will take a closer look at the different phases of relationships, their neurobiological correlates, and key factors of fulfilling long-term relationships.
               
Phase 1: Falling in love
What is often referred to as the first phase of a relationship is a period characterized by high passion, a rapid rise in intimacy, and increased commitment [2]. Elevated cortisol levels help in overcoming initial neophobia [3] and make this phase a stressful period full of excitement and attachment. As serotonin levels are inversely correlated with those of corticosteroids, serotonin is depleted. Testosterone levels show a gender-specific difference at the beginning of a relationship as they are decreased in men but elevated in women [2]. Reduced activity in different brain areas is observable, for example in the frontal cortex, which explains why people who are in love are not able to judge their partner’s character honestly [4] (see also "Through Rose-Colored Glasses" on pp. 16). This phase usually lasts for half a year.

Phase 2: Passionate love
The second phase is a more settled phase dominated by feelings of safety, calmness, and balance that lasts several years. Passion remains high while intimacy and commitment rise. Testosterone, cortisol, and serotonin levels have returned to normal [2]. The key players of this phase are oxytocin and vasopressin as they are responsible for the formation of strong long-term pair-bonds [2] (see also 'Love is Chemistry', in this issue).

Phase 3: Companionate love
Over the years, intimacy and commitment grow, whereas passion decreases. Compassionate love is a “warm” love that is more similar to intimate friendship than to a couple in the first phase, where physical attraction and desire are more prominent [2]. The essential hormones are also oxytocin and vasopressin, restating and maintaining the pair-bond between a couple [5]. The transition from passionate to compassionate love is a critical point in the course of a relationship; when passion has decreased and intimacy is also low, commitment may be all that is left. This is referred to as “empty love” [6] and is usually not sufficient for the continuation of a relationship.

Breaking up
If a relationship comes to an end, it is usually experienced as an unpleasant event, with increased levels of stress hormones [2]. Recent studies of brain activity patterns found increased activity in areas active during choices for uncertain rewards and delayed responses, reflecting a common feeling of uncertainty about the future [7]. Rejected individuals showed a decreased activity in brain networks involved in the onset of major depression and also showed depressive symptoms, suggesting that the grieving period following a break up might be a major risk factor for clinical depression [8].



Triangular theory of love           
Based on the aforementioned three components “intimacy”, “passion”, and “commitment”, Sternberg postulated the “triangular theory of love” in 2007. Basically, this theory correlates combinations and intensities of the distinct components with different experiences of love (see figure). He hypothesized that love progresses in predictable ways and that all couples experience love in the same patterns [6]. Also, a long-term relationship would be more likely to develop when more than one component is experienced. The complete form of love, also referred to as “consummate love”, thereby arises from a strong expression of all three components and is theorized to be that love associated with the “perfect couple”. According to Sternberg, these couples will continue to have great sex fifteen years or more into the relationship, they cannot imagine themselves happier over the long-term with anyone else, they overcome their difficulties gracefully, and each delights in the relationship with the other. A state that sounds desirable. But Sternberg also points out that maintaining this state is highly dependent on a successful translation of the components into action and that consummate love may not be permanent [6].
All in all, it seems that a fulfilling long-term relationship is not accomplished by just finding “the one”. It is rather a co-operation between two passionate and highly motivated partners working together. If this co-operation is based on trust and respect, if problems are solved diplomatically and if progress is evaluated from time to time, it can result in something really great and satisfying.

[1] Kalmijn, Popul Stud, 2007
[2] De Boer, Neuroscience, 2012
[3] Marazziti, Psycho Endo, 2004
[4] Volz, Curr Opin Neurol, 2006
[5] Starka, Prag Med Rep, 2007
[6] Sternberg, Triangulating Love,2007
[7] Fisher, J Neurophysiol, 2010
[8] Stoessel, Neuropsychobiology, 2011

by Betty Jurek, PhD Student AG Prüß
This article originally appeared 2014 in CNS Volume 7, Issue 2, Neuroscience of Love






February 14, 2018

The Evolution of Love


Let me tell you about the birds and the bees. And the flowers and the trees. And a thing called love…
But hey … what is LOVE, except for the most popular topic of song lyrics?

What is Love?
The urban dictionary gives the following definition: “Love is nature’s way of tricking people into reproducing” [1]. Hm… why didn’t we just continue to be self-copying RNA as described in “The Selfish Gene” by Richard Dawkins, or simply procreate by cell division [2]? The clue is that sexual reproduction brings enormous advantages in terms of fitness: Mutations occur naturally in every organism all the time. Some may be harmful, some without impact and others may be highly beneficial. Maybe a mutation in a structural protein could give a protist sturdier ciliaries, allowing it faster movements and a great advantage in escaping predators. However, only the individual carrying the mutation will benefit from it unless it is shared. And basically, sexual reproduction is nothing else but sharing your genome with someone else. This someone will not benefit in person, but his and your offspring will. Thus sharing is caring. But does caring equal love?

Source

I'm Too Sexy...
In general, mating means higher cost for an individual at first, but pays off with increased fitness of its progeny and gene propagation. But of course, not every individual wants to mate with any other. Hence, mating strategies developed to maximize benefit. Mating strategies vary in complexity: a pretty straightforward strategy is to release attractive molecules to acquire a random partner. However, the more costly the reproduction itself, the more prudence in partner choice is advised. The decision about a partner is usually made by the female, thus males of many animal species have developed specific attributes and/or courtship behaviors that may not serve any practical purpose other than attracting a female’s attention and influencing her choice.
Birds give great examples of this: peacocks grow their beautiful and immense tails to impress females. These have no use other than to signal “I am so fit and healthy, I can afford an entirely useless, giant plumage!” (see also 'You Have Beautiful Eyes, Hundreds of Them'). Similarly, bowerbird males construct little lodges from sticks, grass, and leaves, which they even decorate with flowers, shells, and other colorful and shiny things they collect. If the lodge is impressive enough and the female decides to mate, they entirely abandon the lodge to build a nest suitable for breeding elsewhere.
Humans, too, possess attributes that serve reproductive rather than survival purposes. Compared to other primates, humans have features such as “concealed ovulation, extended female sexuality when not fertile, large visible breasts even when not lactating, large spongy boneless visible pensises relative to body size even when not sexually aroused, relative hairlessness that reveals skin quality, full lips that may mimic female genitalia by exposing skin that simulates mucosal membranes”, as discussed in detail by psychologist Lawrence Josephs [3].

You and Me, Forever
But mating alone does not yet guarantee successful procreation. A lot of further effort needs to be invested by parents to actually ensure the survival of offspring, especially in higher mammals. For humans, this can be up to twenty years! For this purpose, nature developed strategies beyond the "hit and run" approach to make mating partners cooperate until their progeny can survive on its own. Bonding mechanisms cause partners to team up and cooperate until descendants can survive independently [3,4]. This may lead to monogamy (or serial monogamy) as a favored type of relationship.
Nowadays, psychologists discuss compassion, a feeling most of us would also associate with love. Compassion also developed to ensure survival chances for vulnerable offspring because it motivates individuals to join forces and cooperate for the sake of their progeny [5]. Even early evolutionists such as Darwin considered what he called “sympathy” to be one of the strongest human instincts. While all of this totally makes sense, it does not really fit our modern-day definition of “love”.



LOVE IS THE ONLY SOCIALLY ACCEPTED FORM OF MADNESS


Maybe, it is more appropriate to talk about the psychological term “romantic love”. Psychologist James Leonard Park provides a sarcastic explanation of romantic love as a hoax or urban legend [6]. Indeed, considering archeological finds from the beginning of mankind, there is evidence for different forms of courtship behavior and for the concept of marriage, i.e. partnership between man and woman in order to maintain monogamy and raise children. Still today across the globe, people get married for practical reasons only, without any romantic consideration. Where does romance come into play then? Apparently, it is the relatively modern invention of medieval troubadours and minstrels in France [7]. Since then, European culture has spread all over the world, the newly invented concept of romantic love has entered folk psychology and is ubiquitous in songs, novels, television, and movies. Cultural imprinting, one could say.


You Drive Me Crazy
Nonetheless, most of us have experienced romantic love, and it is commonly perceived as an altered state of consciousness or “the only socially accepted form of madness” [8]. Not only because of these definitions, involving consciousness and insanity, psychologists and neurobiologists began to explore what underlies romantic feelings in the brain. Even though research has so far correlated brain regions and autonomous nervous system activity with feelings of love and identified some brain chemistry that elicits affection, science is far from answering the question: What is love?
It's good to know that instead, there are plenty of songs still to come that can tell us the answer.

[1] http://bit.ly/1fTAtUl
[2] Dawkins, "The Selfish Gene", Oxford University Press, New York, 1976
[3] Josephs, Am Acad Psychoanal Dyn Psychiatry, 2010
[4] De Boer, Neuroscience, 2012
[5] Goetz, Keltner and Simon-Thomas, Psychol Bull, 2010
[6] http://bit.ly/1mHJD9x
[7] http://bit.ly/1g2veC6
[8]http://bit.ly/1nnGFXd

by Bettina Schmerl, PhD Student AG Shoichet
This article originally appeared 2014 in CNS Volume 7, Issue 2, Neuroscience of Love

February 12, 2018

Why women leave academia and why universities should be worried



Despite the high number of female undergraduate and PhD students, most higher positions in academia, namely professorships, are given to men. A recent study in the field of Chemistry aimed to enlighten the underlying reasons [1]. 

First, it is important to look at the pool of applicants from which universities recruit their top staff. In a prior study, PhD students were asked about their career plans at different stages of their PhD [2]. At the beginning, obviously, both men and women are enthusiastic about pursuing a career as researcher, both in academia and industry: This intention is expressed by 61 % or 72 % of first-year male and female PhD students, respectively. However, in the third year of their PhD, women changed their mind dramatically. Whereas 59 % of men still see research as a career option, only 37 % of women do so.
If one separates between a career intention in industry and in academia, only 12 % of women and 21 % of men see their future in academia. In other words, 88 % of female PhD students and 79 % of their male fellows don't want a career in academia. Curt Rice describes this as an alarming result for universities, as they may no longer be capable of attracting the best and the brightest minds [3].
Both genders, but especially women, regarded an academic career as all-consuming and competitive. First of all, the short-term nature of most post-doctoral positions implies frequent relocation and a lack of security about future employment. The level of competitiveness to achieve a permanent position is seen as very fierce and the impression of young scientists is that it has become harder to get a first foothold on the ladder, especially under the circumstance of a constant hunt for funding [1].

female PhD students feel more affected
 
However, there are several issues that affect only women keeping them away from academic careers: There is a lack of positive examples, as most women feel that female professors often show a quite masculine behavior and are, in many cases, childless. They do not want to sacrifice their personality and their plans for a family, to an academic career. Whereas both male and female PhD students report poor supervision, frustrating experiences in the research process, and problems within the research group, women feel more affected and restricted by this and are more likely to see this as a personal failure. A relevant number of women also report that they were told that their gender might be a problem for a future academic career [1].
Although these studies were focused on Chemistry, it seems to be likely that it is not much different in other subjects. Obviously, the pool from which universities can recruit their lecturers and professors shrinks, and especially women are not attracted by an academic career. Universities should ask themselves if the working conditions and career paths they offer are suitable to encourage talented young researchers staying in academia. Without young and innovative researchers, cutting-edge research at universities is endangered. But considering recent headlines about the German Max-Planck-Society and its plans to cut PhD students from social security system [4], a fundamental rethink has not yet begun.

By Odilo Engel, PhD Alumnus Medical Neurosciences, AG Clinical Neuroscience
This article originally appeared 2012 in CNS Volume 5, Issue 4, Fat Gut or Fat Brain

References
[1] Jessica Lober Newsome: The chemistry PhD: the impact on women's retention - A report for the UK Resource Centre for Women in SET and the Royal Society of Chemistry. London, 2008. http://bit.ly/JC2T5m
[2] The Career Intentions & First Employment Destinations of Chemistry PhD Students: A Gender-Based Quantitative Analysis, Royal Society of Chemistry: London, 2008.
[3] Curt Rice: Why women leave academia and why universities should be worried. The Guardian - Higher Education Network, May 24, 2012. http://bit.ly/MTWaB9
[4] Sven Grünewald: Forschungsstipendien - Schwarzarbeit in der Max-Planck-Gesellschaft? Frankfurter Allgemeine Zeitung, June 10, 2012. http://bit.ly/Lrvd7A

You have Beautiful Eyes, Hundreds of Them!

What do people look for in a partner? Many of us would love to know what aspects of our appearance are of most interest to potential mates. Well, we could start by posing the question 'What do people look at in a partner?' After all, what the eye does not see, the heart does not grieve over or in this case throb for.

Avian Eyetracking Shows Peahens Checking Out Males' Train Feathers
This is one of those research questions, however, where straightforward questionnaire data are likely to raise suspicions. How many people are going to admit that they look straight at someone's buttocks or cleavage? Eyetracking, on the other hand, can reveal a great deal about what people attend to, and has delivered such edifying conclusions as: Men seem to like to assess each other's crotches [1]; women check each other out as much as they do men [2]; and men look longer at larger breasts (even when controlling for the larger area of the visual field they occupy) [3].


Picture reproduced with permission from Yorzinski et al, J Exp Biol, 2013

A recent novelty, however, is the application of eyetracking to the romantic interests of birds. And no better bird to begin with than the peacock, famous for its eye-catching train of iridescent feathers, rattled in mating displays. Of course, in the animal kingdom it tends to be the women who do the ogling, so a recent study tracked peahens' eye movements while the males strutted their stuff [4].
The peahens were not especially impressed, spending less than a third of their time even looking at the male at all. Nor were they interested in everything he had to offer. The upper train, where most of the eyes are located, was of relatively little interest. Instead, the females' gaze lingered on the lower train, which they scanned from side to side in a way that suggests they were assessing its symmetry, an important feature in sexual selection [5].
So how can we make sure our next date results in love at first saccade? The authors offer a somewhat disheartening speculation. Briefer viewing times may indicate simply that a trait is much easier to assess. Peahens may look less at train eyes simply because it is very easy to see whether a male has fewer than required, and he may then be rejected without further ado [6]

[1] http://bit.ly/NCem7I
[2] Rupp and Wallen, Horm Behav, 2007
[3] Gervais et al, Sex Roles, 2013
[4] Yorzinski et al, J Exp Biol, 2013
[5] Moller and Thornhill, Amer Nat, 1998
[6] Dakin and Montgomerie, Anim Behav, 2011

by Luke Tudge,
This article originally appeared 2014 in CNS Volume 7, Issue 2, Neuroscience of Love 

February 09, 2018

Mirror Mirror on the Wall - An Insight into Narcissistic Personality Disorder

Having a conversation with a person with an inflated ego is always a very tiresome experience. We are constantly pushed into praising the other person, for criticism is not well received and often disregarded. Narcissism refers to the pursuit of gratification from the egoistic admiration of one’s own physical or mental attributes. 

Narcissistic personality disorder (NPD) is characterized by a lack of empathy as well as a need for admiration and a pervasive pattern of grandiosity [1]. It has prevalence rates of up to 6% in the general population and pathological narcissism is considered a severe mental disorder, associated with significant functional impairments [2].

What Leads to NPD?
Although it is difficult to pinpoint a single cause for the disorder, it is thought to result from extremes in child rearing. On the one hand, it could arise from excessive pampering. On the other, neglect, abuse or trauma inflicted by the parents or other authority figures during childhood could also lead to narcissism, which is usually evident by early adulthood. As a consequence, narcissistic individuals always need people around them, as their entire sense of self-worth is dependent on the admiration of others.


The Neurobiology of Narcissism
From a neurobiological perspective, studies with people suffering from NPD have led to interesting findings. Ritter et al. showed that patients with NPD had severe deficits in emotional empathy although they had intact cognitive empathy.  Emotional empathy requires subjects to rate how much of the emotion in a picture they feel when they view an emotional picture, while cognitive empathy is determined by asking subjects to infer the mental state of a person in the picture [3]. Another study using functional magnetic resonance imaging found that healthy subjects scoring high on a Narcissism Inventory also showed significantly decreased activation during an empathy task, especially in the right anterior insula [4]. Psychotherapy and medication are the currently available treatment options. Identifying the feelings of vulnerability and impaired self-reflection as the core features of the disorder can lead to better psychological treatments.

[1] American Psychiatric Association, 2000
[2] Stinson et al, J Clin Psychiatry, 2008
[3] Ritter et al, Psychiatry Res, 2011
[4] Fan et al, Psychological Medicine, 2011

by Apoorva Rajiv Madipakkam
This article originally appeared 2014 in CNS Volume 7, Issue 2, Neuroscience of Love

February 07, 2018

The Olympic Games and Their Historic Values


The 2018 Olympic Winter Games in south Corea are coming up, an over two-week event offering an innumerable amount of sports. Who came up with the idea of the Olympics, though? The Olympics are always considered to be of Greek descent, but are they really?

The Ancient Games
The first Olympic Games were held in 776 BC in ancient Greece. The Games were held in the city of Olympia, at the foot of Mount Olympus, the mountain where the Greek Gods were said to live. This location was chosen, as the Games were one of the two great religious events celebrated in honor of the Greek Gods. Honor was what drove athletes of every city to participate as well. Winners were awarded with an olive wreath, the symbol of peace and distinction, and eternal prestige. In 394 AD, the Games were banned by the Roman emperor Theodosius I, who considered the Greek celebrations a pagan event [1].

Revival of the Games
For almost 1500 years no-one thought of this Greek festivity. But then the French baron Pierre de Coubartin started sharing his dream of reviving the Ancient Games. His lobbying resulted in the first Modern Olympic Games, held in Greece in 1896. The foundation of the Games was based on what de Coubartin said: ‘The important thing in life is not the triumph but the struggle, the essential thing is not to have conquered but to have fought well’. He founded the International Olympic Committee, which today still decides where the Olympics will be held and which sports will be a part of the Games [2]. In memory of its founder, the Pierre de Coubartin medal was invented and awarded to athletes who show true sportsmanship.
The olympic rings, source: http://bit.ly/1VpM2Gs


Symbols and Traditions
The Olympic motto ‘Citius, Altius, Fortius’ (Latin for ‘faster, higher, stronger’) exists since 1896. The symbol and flag, with the five colored rings intertwined on a white background, were designed in 1914. Both the motto and symbol come from Pierre de Coubartin. The symbol contains all the colors necessary to make the flags of all participating countries at the time. The rings resemble continuity and the human body [3]. New traditions have been added since - the relay carrying the Olympic fire from Greece to the host city of the Games, was started for the 1936 Berlin Games.

Sports
In its final days, the Ancient Games included 7 sports while in the very beginning the festival consisted purely of running events [1]. The first Modern Olympics consisted of nine sports, a number that has risen over the years and has been set to a maximum of 28 sports in the early 2000s. As a rule, a sport can only be admitted to the Summer Olympic program when it is widely practiced in at least 75 countries spread over four continents. Since 1936, the only changes in sports have been the dismissal of baseball and softball in the Olympics of 2008. The 2016 Olympics will see the addition of golf and rugby. The first Winter Games were organized in 1924, and always included skiing, skating, and ice hockey. The maximum number of sports in the Winter Games is seven, and to be included they need to be practiced by 25 countries, spread over three continents [4].

“IMPORTANT IS NOT THE TRIUMPH BUT THE STRUGGLE”

Olympism
The values and ideals of the Olympic Games are written down in the Olympic charter. The philosophy following these fundamental guidelines is called Olympism. The Olympic Movement has six pillars: Sport for All, Development through Sport, Women and Sport, Education through Sport, Peace through Sport, as well as Sport and Environment [1].
To conclude, the Modern Olympic Games, though based on the Greek Ancient Olympic Games, were invented by the French Pierre de Coubartin. The number and types of sports have changed over time, however, fundamental values of sportsmanship and honor have always been the basis of the Olympic Games. As for relations to Greece, one of the traditions of the Modern Games, carrying the Olympic fire from Olympia, Greece, to the host city of the current Games, hints that people still prefer a mythical touch to this event of great emotion and mighty athletes fighting for honor, as it was more than two eras ago in Greece.

Differences between the Ancient and Modern Games:

Ancient GamesModern Games
First edition776 BC1896 AD
Last edition394 ADongoing
Inventor'Greek Mythology'Pierre de Coubartin
Number of sports728
ParticipantsFree Greek menAthletes from all over the world
Length5 days17 days
PhilosophyMythology: offerings to ZeusOlympism

[1] www.olympic.org 
[2] http://bit.ly/1XCUoH4
[3] http://bit.ly/1Q9JZ0S
[4] http://bit.ly/1SPJydY

by Judith Houtman, PhD Student AG Heppner
this article originally appeared June 2016 in Volume 09 Issue 2 "The Sporty Brain" 

February 05, 2018

High Impact: Consequences of Brain Injury in Athletes

Who has watched the Super Bowl last night? It had more than 111 million spectators. Besides watching a great sports game and an amazing halftime show, viewers were also witnessing series of brain concussions.

In football, players run like bulldozers, ramming everyone in their way. If the heads of two football players collide, the impact can reach up to more than 100 g [1], similar to forces in a car crash; a high school football player experiences about thousand blows to the head each season [2]!

Rising Awareness Since 2005
Football has been played since 1869, but awareness that repetitive concussions and sub-concussive hits to the head may have long term neurodegenerative effects has been rising only since 2005. It all started when Bennet Omalu autopsied the brain of Mike Webster, a four-time winner of the Super Bowl who died at the age 50. After retiring from a long football career, he developed depression, took drugs, had memory and concentration problems, as well as shaking hands.
Mike Webster’s brain showed amyloid plaques and neurofibrillary tangles in the neocortex, reminiscent of Alzheimer's disease (AD). Omalu diagnosed chronic traumatic encephalopathy (CTE) and hypothesised that head-to-head collisions were the cause [3]. With accumulating case studies, he also started making connections between repetitive mild brain injuries and depression. Later, a second group led by Ann McKee reported CTE in a larger cohort of post-mortem samples and confirmed many of Omalu's hypotheses [4].

Upon Impact, the Brain Hits the Skull
Helmets worn by the players only prevent skull fractures, but not internal damage; the brain hits the skull from the inside, referred to as “Brain Slosh”. The shearing of brain tissue leads to excessive toxic release of neurotransmitters, changes in glucose-metabolism, immune activation, and damage of blood vessels. This leads to secondary injury: breakdown of the blood brain barrier, disturbances in cerebral blood flow, formation of hematomas, neuroinflammation and so on.
The results are neurological symptoms during acute injury (dizziness, headache, nausea) which collectively persist in long-term deficits [5]. Neuronal damage and traumatic axonal injury further lead to accumulation of a-beta amyloid, tau and ApoE components [5]. Though sharing many similarities with AD, CTE-associated tauopathy differs with regard to the distribution: in CTE, tau is most prominent in superficial cortical layers and sulci, and tends to surround blood vessels [5].
by Jack Kurzenknabe, via flickr


Diagnostic Difficulties
The clinical phenotype of CTE is still incomplete, because most of the knowledge comes from post-mortem analyses and retrospective data. In the 158 autopsy cases analysed so far, 80% showed signs of CTE [6]. However it is difficult to asses how natural age-related changes, unrelated psychiatric illness, alcohol/drug use or coexisting cognitive impiarment contribute to the current picture of CTE; due to the long latency of CTE, co-morbidities are often present.
As of yet, there have been no established diagnostic criteria or in vivo biomarkers, meaning that CTE can only be diagnosed post mortem. But there is hope: Recent research developed means for premorbid identification of neurodegeneration in contact-sports athletes. NFL players with histories of mood and cognitive symptoms were subjected to positron emission tomography (PET) scans, which revealed that they had higher tau deposits than controls in all subcortical regions and the amygdala, areas known to produce tau deposits following trauma [7].
INCIDENCE AND PREVALENCE STILL UNKNOWN
However the incidence and prevalence of CTE are still unknown and, to date, there is no consensus regarding which intensity of head blows is tolerable. Large-scale prospective, longitudinal studies of concussed and non-concussed individuals are needed to provide a better picture.
To further advance the research on biomarkers and treatment approaches, a mouse model has been developed. It uses controlled closed-head impacts on unanaesthetized mice to recapitulate the spectrum of behavioural symptoms noted in patients diagnosed with CTE [8].

What are the Consequences?
Until recently, the National Football league (NFL) did not recognize these injuries as consequence of the sport itself. Rather, a common argument suggests that former players can’t cope with not being the focus of attention anymore, which is why they develop depression and take drugs, which then goes on to eventually cause neurodegeneration. Several former NFL players sued the league for allegedly misleading them about the risks of brain injury and one player even resigned from the NFL because he feared the consequences of the daily brain trauma.

Is This the End for Football?
Football has been played for 150 years. In 1905, 19 players died in a single season, most due to head and spine injuries. President Roosevelt, an avid football fan, ordered football coaches to reform the rules eliminating the more brutal features of the game. Since then, the sport has changed time and again. As a reaction to the current discoveries, President Barack Obama also expressed concern about college football players and the “problems with concussions and so forth” [9]. Football is just too big of a cult for this to be the end. New rules will hopefully be enforced to make the games safer for the athletes and still satisfying for fans.

[1] Funk et al, Ann Biomed Eng, 2012
[2] Beckwith et al, Med Sci Sports Exerc. 2013
[3] Omalu et al, Neurosurgery, 2005
[4] Stein et al,  Alzheimers Res Ther, 2014
[5] Chauhan, Restor Neurol Neurosci,  2014
[6] Gardner et al, Br J Sports Med,  2014
[7] Small et al,  Am J Geriatr Psychiatry, 2013
[7] Petraglia et al, J Neurotrauma, 2014
[9] Foer and Hughes, New Republic, 2013

by Claudia Willmes, PhD Alumna AG Eickholt / AG Schmitz
this article originally appeared June 2016 in Volume 09 Issue 2 "The Sporty Brain"

Interesting movies to watch:

February 02, 2018

Book Review: Bad Science

A Book by Ben Goldacre, a man who signed his dead cat up as a certified professional member of the American Association of Nutritional Consultants to prove a point.

"Let me tell you how bad things have become" begins Bad Science, before describing the Brain Gym exercises currently practiced in British schools. If you, as a budding neuroscientist (or even just as a sane individual), are concerned by the idea of children being taught that nodding their heads vigorously will make them smarter by increasing blood flow to the frontal lobes then you might want to read on. Ben Goldacre, a British doctor, is on a crusade and this book outlines his manifesto. He targets three main audiences and carries them on a crash course through modern science, mainstream media and money-making 'medical' quackery. Goldacre writes for us - scientists - as well as reaching out to people with no scientific education and imploring his 'enemies' - scare-mongering journalists and greedy nutritionists - to see reason.
Book cover of "Bad Science"

The book outlines a clear set of ideas about the advancement of public knowledge of science and Goldacre explains the obstacles he sees to these goals through a series of succinct examples of media debacles and blatant false advertising. Bad Science is the art of misinterpreting statistics, underestimating placebo effects and taking advantage of health worries and scientific ignorance in the general public to make a quick buck. Most of this is explained whilst maintaining a humorous tone - if you like gathering fun facts about the reality of recreational drug use or finding out the truth about 'Horny Goat Weed' aphrodisiacs then this is your book - but he also describes a darker side: the people who don't want to stop making money from dodgy therapies. One chapter is only included in the most recent edition of the book as Goldacre was being sued for libel by its subject, a multivitamin-pill magnate peddling lies in AIDS-striken South Africa.

Check out his TED talk!
As a population with at least basic knowledge of the procedures of evidence-based medicine, we medical neuroscientists may end up feeling a little smug as Goldacre dips into statistics and scientific reasoning. Despite this, for me at least, it served as a necessary reminder that one must always seek the full story beneath anything from a peer-reviewed academic paper to a sensationalised tabloid newspaper article. Although probably preaching to the converted, Goldacre's closing plea to scientists to make sure our work is known and not misinterpreted is sound advice. This book will make you reassess the way you think about science in the media. Please read it (or at least watch his TEDtalk).



by Ellie Rea
this article originally appeared March 2012 in Volume 5, Issue1, "Mental Health Disorders"